| (210) | Number of the EPO application | 19707648 |
| (220) | Filing date of the EPO application | 2019.02.14 |
| (80) | EPO patent specification publication (B) | EPB nr. 49/2022, 2022.12.07 |
| (110) | EPO patent number | 3752510 |
| (11) | Number of the document | MD 3752510 T2 |
| (21) | Number of the application | e 2020 1268 |
| (71) | Name(s) of applicant(s), code of the country | VERTEX PHARMACEUTICALS INCORPORATED, US; |
| (72) | Name(s) of inventor(s), code of the country | CLEMENS Jeremy J., US;
ABELA Alexander Russell, US;
ANDERSON Corey Don, US;
BUSCH Brett B., US;
CHEN Weichao George, US;
CLEVELAND Thomas, US;
COON Timothy Richard, US;
FRIEMAN Bryan, US;
GHIRMAI Senait G., US;
GROOTENHUIS Peter, US;
GULEVICH Anton V., US;
HADIDA RUAH Sara Sabina, US;
HSIA Clara Kuang-Ju, US;
KANG Ping, US;
KHATUYA Haripada, US;
MCCARTNEY Jason, US;
MILLER Mark Thomas, US;
PARASELLI Prasuna, US;
PIERRE Fabrice, US;
SWIFT Sara E., US;
TERMIN Andreas, US;
UY Johnny, US;
VOGEL Carl V., US;
ZHOU Jinglan, US; |
| (73) | Name(s) of owner(s), code of the country | VERTEX PHARMACEUTICALS INCORPORATED, US; |
| (54) | Title of the invention | Macrocycles as modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions thereof, their use in the treatment of cycstic fibrosis, and process for making them |
| (13) | Kind-of-document code | T2 |
| (51) | International Patent Classification | C07D 513/22 (2006.01.01); C07D 515/22 (2006.01.01); A61P 11/00 (2006.01.01); A61K 31/437 (2006.01.01) |
| (19) | Country | US |
| (41) | Date of publication of the application | 2021.01.31 |
| (49) | Date of publication of the translation of the validated European patent specification | 2023.06.30 |
| (30) | Priority | 201862631453 P, 2018.02.15, US |
| (74) | Patent attorney | (Procedură) PARASCA Dumitru, str. Eminescu nr. 40, ap. 13, c/p 28, MD-2012, Chişinău, Republica Moldova |
| (86) | International application | PCT/US2019/018042, 2019.02.14 |
| (87) | International publication | WO 2019/161078, 2019.08.22 |